Dermal fillers based on Hyaluronic Acid have become quite popular, due to the enormous potential of the molecule. New applications for HA are being developed every year in this field and many others. Today’s fillers can almost turn back time by eliminating wrinkles, restoring smooth lines of face and body, making lips expressive and appealing — all while maintaining a natural appearance, and without any surgical intervention.
The key difference between today’s HA-based fillers and yesterday’s synthetic ones is that HA not only literally “fills” space under the skin, it prompts the body to make its own “filling” by stimulating the synthesis of extracellular matrix components.
An innovative Cross-module Technology – the know-how of manufacturers and developers of HA-formulas laboratory Toskani (Russia) is a complex multistep process of stabilization of hyaluronic acid (HA) aiming to obtain a homogeneous viscoelastic compound of highly stabilized hyaluronic acid with less stabilized hyaluronic acid.
First applied in 2007 for manufacturing of products for face contouring.
After further improvements of formulas in 2015 a new generation of preparation, Hyaluform® filler was produced.
In contrast to the classicaltechnologies of fillersmanufacturing, the innovative Hyaluform® filler presents a homogeneous HAsubstance, such as monophasicpreparations but with incorporated\«sealed in» particles of stabilized hyaluronic acid. Itprovides a uniform integrationof fillerin the tissue and guaranties its highformingability.
Multi-stage stabilization of hyaluronic acidobtaining a homogeneous substance of strong stabilized HA with the integration of less stabilized hyaluronic acid.
I phase Alignment along the length of the molecules (by molecular weight)
Solid-phase stabilization of hyaluronic acid
with the equability of molecular weight distribution
II phase Formation of uniform particles
Stabilization of terminal hydroxyl groups,
the creation of uniform particles
III phase Integration
Formation of spatial-structural relationships between strong and less stabilized HA on the base of «cross-module» principle.
CHARACTERISTICS: THE HOMOGENEITY AND HIGH PLASTICITY OF THE
SUBSTANCE, THE SPECIFIED HA PARTICLE SIZE, OPTIMIIZED PROPERTIES.